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Moreover, disruption of autophagy-related genes such as Atg5 and Atg7 also suppresses Erastin-induced ferroptosis, indicating the involvement of autophagy-dependent mechanisms in this process ( , a cystine/glutamate antiporter composed of SLC7A11 and SLC3A2

however, this is FDA staff's proposed position going into the meeting, not a final action, and the committee's discussion, any vote, and FDA's ultimate decision are still pending, so the outcome of the review is not yet known

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Supplementing with NAC bolsters up cysteine levels in the body, therefore supporting glutathione production

Indications for using dexamethasone