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Coskun et al

Increasing age Having family members with vein problems Hormonal changes during puberty, pregnancy, and menopause, or from birth control pills Increased amount of blood and pressure of the expanding uterus during pregnancy Obesity, leg injury, prolonged standing, and other things that weaken vein valves Why do varicose veins and spider veins appear

Tissue repair Studied preclinically as a pentadecapeptide involved in tissue repair, with animal research exploring wound-healing and cellular recovery pathways

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