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The metabolic clearance occurs by proteolytic cleavage of the tirzepatide peptide backbone, -oxidation of the C20 fatty diacid moiety, and by amide hydrolysis

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N Engl J Med 380:347357 Zelniker TA, Wiviott SD, Raz I, Im K, Goodrich EL, Bonaca MP et al (2019) SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials

-Cell failure in diabetes: common susceptibility and mechanisms shared between type 1 and type 2 diabetes

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