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We found that prolonged exendin-4-induced insulin secretion was increased in INS-1 832/3 and MIN6B1 cells after treatment with small interfering RNA (siRNA) to silence both -arrestins, and also in human EndoC-H1 40 beta cells lentivirally transduced with -arrestin-1 and -arrestin-2 small hairpin RNA (shRNA) (Fig

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