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Clinical trials in which GDNF was injected directly into the brain did not yield much success either (Whone et al., 2019)

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Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment

They found that if the Centers for Medicare and Medicaid Services provided coverage for these medications for obesity, the cost of Medicare Part D plans would rise by $66 billion over the next 10 years, and Medicare plans would get $18 billion in savings from improved health

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