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373 In fact, when BMSCs are exposed to exendin-4, the expression of genes related to bone development factors such as Runx and Osterix, as well as genes responsible for producing the bone matrix such as Balp and Bglap, is upregulated

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Some common side effects may include nausea, headache, flushing, or a slight increase in blood pressure

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Compounded versions are made in pharmacy back rooms using semaglutide powder of variable origin, often with vitamin B12 or other additives marketed as "performance enhancers." A 2024 review of the legal and safety considerations around compounded injectable semaglutide flagged four recurring problems: The active ingredient often comes from non-FDA-registered foreign suppliers, with no guarantee of purity or potency Some compounded products use semaglutide salts (sodium or acetate forms) that the FDA has not approved and that haven't been studied for safety in humans Dosing errors have been common, including patients accidentally injecting 10 times the intended dose because of confusion between micrograms and milligrams Marketing claims about "personalized doses" or B12 add-ins are not supported by clinical trial data A 2025 medical news follow-up documented cases where patients receiving compounded semaglutide reported pancreatitis, hospitalizations from accidental overdoses, and lab-confirmed contamination