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However, under oxidative stress conditions, Nrf2 dissociates from Keap1 and translocates to the nucleus, where it activates various antioxidant genes, including HO-1, protecting cells from oxidative damage

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Excessive mitochondrial ROS (mtROS) production can suppress immunoglobulin production via T-cell-dependent antigens 20

We tend to underestimate what it takes to implement meaningful change, which is often as dependent on our environment as it is on our behavior

While these modified drug candidates have only been shown to be effective for certain diseases, they also have the potential for treating other diseases associated with ferroptosis