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Your provider will then increase the dosage over time if needed

doi: 10.1093/humrep/deac013 2 EhrmannDA

Su CF, Chen YF, Tsai YJ, Weng SM, Jan JS

In OA cartilage, MQC dysfunction leads to abnormal mitochondrial tricarboxylic acid (TCA) cycle function, accumulation of metabolic intermediates such as -ketoglutarate and succinate, which affect epigenetic modifications by regulating the activity of histone demethylases, driving abnormal proliferation and aggregation of chondrocytes

Similar to succinate, fumarate contributes to the inactivation of PHD, stabilizing HIF proteins to promote cell survival 133 (Fig

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