Konerman MA, Jones JC, Harrison SA (2018) Pharmacotherapy for NASH: current and emerging
Moreover, activated HSCs produce ROS and transforming growth factor- (TGF-) (Figure 4)
Low ferritin levels may indicate an iron deficiency
Pharma is innovating to hit even more targets The latest article I saw about the work being done in this class is a study in mice looking at a quintuple agonist (5 different targets!) I almost never write about mice studies because of how preliminary they are and how unlikely a finding in mice is to ever translate into anything useful in humans, but because of the success weve already seen of this drug class as well as the way that hitting more pathways seems to increase efficacy, I thought this was research worth highlighting
Cagrilintide works through an entirely separate system, the amylin receptor pathway, targeting different neuronal populations in the brainstem that regulate satiety and appetite
It dissolves readily in water and should be stored refrigerated at 28 C