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doi: 10.1016/j.it.2020.11.002 55 De FloraS.BalanskyR.La MaestraS

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IGF-1 LR3 activates IGF1R with high affinity and can activate hybrid IGF1R/IR receptors to some degree

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BPC-157 upregulates VEGFR2 expression in vascular endothelial cells at both mRNA and protein levels without increasing VEGF-A production, suggesting the peptide sensitizes endothelial cells to existing VEGF rather than simply increasing ligand availability