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Third, HF-specific outcomes such as functional capacity, quality of life, congestion burden, and recurrent hospitalization have been inconsistently reported

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These effects were associated with decreased androgen receptors, mTOR and AKT expression signaling, and increased caspase-3 activation 35

doi: 10.1016/j.neulet.2004.09.059 97

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unmeasured or imperfectly measured variables not captured in the electronic health recordsuch as socioeconomic status or specific lifestyle interventions (eg, diet, exercise)could still bias the results if they were associated with both treatment initiation and the outcomes