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IV glutathione use has been linked to serious adverse effects such as liver failure, kidney failure, and Stevens-Johnson syndrome, calling into question its safety

Gastrointestinal absorption of vitamin B 12depends on the presence of sufficient intrinsic factor and calcium ions

[Establishes Cortical Spreading Depression mechanism]

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[4] Clinical practice typically involves reviewing medication history, assessing liver function, performing a full blood count, and considering haematological or hepatological referral when levels are markedly elevated without clear cause

Indeed, Se supplementation increases the ratio of total cholesterol to significant HDL cholesterol in the plasma, suggesting a potentially beneficial effect on cardiovascular risk supplementation [77]