In this review article, we highlight the current understanding of the clinical efficacy and the mechanisms underlying the effects of GLP-1RAs in DKD
In the past year, there was news about the prevention of progression to diabetes with tirzepatide (Mounjaro/Zepbound, Eli Lilly), benefits of tirzepatide and semaglutide (Ozempic/Wegovy, Novo Nordisk) in other patient populations such as those with heart failure and chronic kidney disease, and mounting evidence for the triple-hormone agonist retatrutide (Eli Lilly)
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doi: 10.2337/diacare.23.8.1154 26 GreenmanYTordjmanKSternN
Tirzepatide activates two hormone receptorsGLP-1 and GIPto reduce appetite and improve metabolic control, while L-carnitine transports fatty acids into mitochondria for energy production