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Weight management is typically a gradual process, and response timelines cannot be predicted

Combined Risks and Considerations When semaglutide and TRT are used together, its important to consider how their effects might interact

The mechanism may involve cytokine release at the injection site, with inflammatory mediators diffusing to nearby muscle tissue

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Nat Rev Cardiol 21(2):69 Kushner RF, Ryan DH, Deanfield J, Kokkinos A, Cercato C, Wilding J et al (2025) Safety profile of semaglutide versus placebo in the SELECT study: a randomized controlled trial