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Market entrants targeting oral or multi-agonist mechanisms are intensifying competition, but incumbents retain strong negotiating leverage because they control most commercial-scale peptide production
CONCLUSION The analysis of GLP-1 products, such as semaglutide and tirzepatide, reveals how a financialized pharmaceutical business modelexorbitant pricing, patent abuse, and restricted insurance coverageperpetuate health inequities and limit access to critical treatments
Lancet 366 , 11971209 (2005)
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The second problem: innovator companies were losing years of patent-protected revenue while drugs sat in FDA review, and had no statutory mechanism to recover that lost time
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