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Economic modeling in patients with obesity and knee osteoarthritis suggests that both semaglutide and tirzepatide would generally be considered cost-effective compared with usual care, with tirzepatide offering the more favorable return on investment once willingness-to-pay thresholds exceed $57,400 per QALY (Betensky et al., 2025)

Funding This work was funded by the Yunnan University Undergraduate Innovation Fund, S202410673138, Yunnan University Medical Research Foundation Department of Radiology, YDYXJJ20250024, Yunnan University Graduate Research Innovation Fund, KC-252512222

Dark spots, also known as hyperpigmentation, are patches of skin that have more melanin than the surrounding skin