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Exp Clin Endocrinol Diabetes (2013) 121(04):2348
Oral bioavailability ranges from 1030% due to first-pass hepatic metabolism and gastric degradation, while subcutaneous injection achieves near-100% bioavailability with direct systemic distribution
It is included here for completeness because the mechanism melanocortin receptor activation in neural tissue is well-characterized, and it may explain some of the subjective cognitive effects users occasionally report
Mutation of this enzyme leads to fumarate accumulation not only in skin cancer and uterine leiomyomas but also in breast, bladder, and Leydig cell tumors 130
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