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This preserves the neuroendocrine rhythm that regulates cellular repair, skin collagen turnover, hippocampal memory consolidation, and immune function

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51 (Suppl 1): S355

MY-5445, a phosphodiesterase type 5 inhibitor, resensitizes ABCG2-overexpressing multidrug-resistant cancer cells to cytotoxic anticancer drugs

The findings established Ipamorelin's defining characteristic: Growth hormone Ipamorelin produced dose-dependent GH release comparable to GHRP-6 Cortisol No significant cortisol elevation was observed with Ipamorelin, while GHRP-2 and GHRP-6 produced measurable cortisol increases Prolactin No significant prolactin elevation at GH-effective concentrations ACTH No significant ACTH stimulation, contrasting with the adrenocorticotropic effects of other GHRPs GHRP Selectivity Comparison (Preclinical Data) Compound GH Release Cortisol Effect Prolactin Effect ACTH Effect Ipamorelin Dose-dependent Minimal / none Minimal / none Minimal / none GHRP-2 Dose-dependent Moderate increase Moderate increase Moderate increase GHRP-6 Dose-dependent Moderate increase Moderate increase Moderate increase Hexarelin Strong Significant increase Significant increase Significant increase Data adapted from Raun et al

Methods Fish husbandry and samples collection All the killifish used in this study are from the GRZ strain