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Semaglutide carries a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and is contraindicated in patients with a personal or family history of MTC or Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Women should not take GLP-1s or other weight loss medications while pregnant, breastfeeding, or trying to conceive

GLP-1 and menstrual cycles: common, but not predictable changes For many women, the first noticeable shift is their cycle

Who Should Avoid PT-141 Uncontrolled hypertension PT-141 can cause transient increases in blood pressure

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Though these agents do increase arousal threshold in OSA with a modest improvement OSA severity [86, 87], they may have the potential for neurological depression and worsening of hypoxemia associated with OSA at higher doses