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Interestingly, inhibition of adrenoceptor beta 2 (ADRB2) has been shown to attenuate fibrosis by suppressing SMAD2/3 phosphorylation and promoting proteasomal degradation of phospho-SMAD2/3 in lung fibroblasts [42]

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they have each had decades of human trials, been FDA approved, and are approved for multiple medical uses

Typical oral protocols use 0.5 mg to 1 mg daily, often split into two doses taken morning and evening

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Quantitative real-time PCR (qRT-PCR) Total RNA was isolated from pancreatic tissues and cultured PSCs using TRIzol reagent (Beyotime)