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The E MAX value indicates the maximum BRET signal as fold-change from baseline
Methods Cell culture INS-1 832/3 rat insulinoma cells were maintained in RPMI-1640 at 11 mM D-glucose, supplemented with 10% fetal bovine serum (FBS), 10 mM HEPES, 2 mM L-glutamine, 1 mM pyruvate, 50 M -mercaptoethanol and 1% penicillin/streptomycin
It is studied in experimental models for effects on body composition, lipolysis, and IGF-1 modulation without significant cortisol or prolactin elevation.
Less muscle means lower calorie burn at rest, increasing the risk of weight (re)gainprimarily as fatwhen the medication is stopped
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Lillys approval for Mounjaro in Obesity will result in a duopoly in the space, with clinical stage biopharma (mentioned below) likely 2 years from having a drug on the market
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