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(3) Fig 1

Patients with a history of diabetic retinopathy should be monitored appropriately, and any visual changes should be reported promptly

Each dose increase represents a physiological adjustment period during which side effects may temporarily intensify before stabilizing

Only a licensed clinician can evaluate whether this is appropriate for a specific health history

Some people notice mild fatigue or queasiness during this period, particularly if calories fall too fast or hydration lags

Eli Lilly anticipates regulatory submissions by the end of this year for orforglipron as a once-daily weight management medicine