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The safe upper daily limits for taking Vitamin B12 are 2000mcg* or less a day

However, more research is needed to understand how durable these changes are without medication

doi: 10.1007/s00125-015-3795-1 18 RazIFonsecaVKipnesMDurrwellLHoekstraJBoldrinMet al

Additionally, in recent post-marketing surveillance based on individual reports of adverse events while using semaglutide, 19 out of 28,954 (0.07%) reported SLE-like symptoms