Case reports and expert consensus instead highlight that tirzepatide alone achieves superior long-term weight loss (average 22 pounds at 21 weeks in STEP trials) without the tolerance decay that limits phentermine to 12 weeks of use
Patients who develop symptoms of pancreatitis (e.g., upper abdominal pain radiating to the back, nausea, vomiting) should be evaluated promptly, and tirzepatide should be discontinued if pancreatitis is confirmed
Insulin sensitivity and metabolic flexibility Both compounds improve insulin sensitivity, but through different mechanisms
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