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They affect dopamine release, which is your brains way of saying this feels good. When you take a GLP-1, those reward pathways get dialed down
In fact, their Google ad says Lose 15%+ of your body weight in one year on average with FDA-approved GLP-1 medications, which is a bit misleading because compounded medication is not FDA-approved
Curated affinity data instead describe a full agonist at four of the five human melanocortin receptors: reported pIC 10.0 at MC1R, pKi 8.9 at MC3R, pKi 8.5 to 8.8 at MC4R, and pIC 9.0 at MC5R, with no activity at MC2R, the adrenocorticotropin receptor, which is not engaged by alpha-MSH analogues of this class
Patients with significant diabetic retinopathy were excluded from tirzepatide trials
Given that we cant survive without these other substances, the fact that we have so much glutathione around tells us that it is just as important
Wilding JPH, et al
