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GluK1-GluK3 are low affinity KAR subunits, due to relatively high concentration of agonist needed for their activation (K D for [ 3 H]kainate, 50100 nM) compared to GluK4 and GluK5 which are high affinity subunits (K D for [ 3 H]kainate, 5 nM) (Figure 1B)

Summary: This preclinical study investigated the mechanism of action of Cagrilintide in animal models

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Espe M, Lai F, Gomes AS, De Santis C, Hartviksen MB, Holen E, Rnnestad I

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In published pre-clinical studies, both peptides are most commonly administered via subcutaneous (SubQ) or intramuscular (IM) injection