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For a general deficiency, many protocols start with 100 mcg injections daily or every other day for the first week
Powell CR and Kreder KJ: Long-term outcomes of urgency-frequency syndrome due to painful bladder syndrome treated with sacral neuromodulation and analysis of failures
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What remains unclear is whether those mechanisms translate to symptom relief in humans with reflux disease
You should get B12 shots weekly to monthly for maintenance and IV infusions monthly to quarterly for broader wellness support, though frequency depends on deficiency severity, health goals, and your providers recommendation
