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Triple action mechanism After being absorbed through the nasal mucosa, MT-2 peptide rapidly reaches the hypothalamus via the trigeminal-sympathetic nerve pathway, activates the melanocortin receptor system, and triggers the release of melanocyte-stimulating hormone from the pituitary gland, forming a "neuro-endocrine-skin" cascade reaction

Melanotan 2 is often researched for melanin-production pathways associated with tanning response

Nakamura, H., Hoshino, Y., Okuyama, H., Matsuo, Y

Conditioned or seeking strong stress: Traditional sauna with short, hotter bouts