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The ROS produced upon engagement of these receptors can then alter downstream signaling by oxidizing specific cysteine residues within a variety of intracellular proteins including protein kinases, protein phosphatases, adaptor proteins, calcium channels, and transcription factors

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PROTEINS INVOLVED IN CYTOSOLIC IRON DISTRIBUTION: MONOTHIOL GLUTAREDOXINS In addition to its role as a ligand in the cytosolic LIP, GSH coordinates iron as part of the FeS carrier complex formed by cytosolic monothiol glutaredoxins (reviewed in Rouhier et al., 2010)

Some discontinued clinical trials (for example in postoperative ileus) failed to demonstrate sufficient efficacy in primary endpoints, although certain biological signaling effects remained measurable and scientifically relevant

Histology and Immunostaining For cell staining, the testicular cells were seeded on 18 mm glass coverslips in a 6-well plate (BD Biosciences, Franklin Lakes, NJ) and treated with 0300 M DZN for 24 h with in vitro culture

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