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Readings above 300 mg/dL warrant immediate medical attention

PLoS Comput Biol (2012) 8(9):e1002687

For example, abnormal levels of erythrocyte sedimentation rate (ESR), hematocrit (HCT), whole blood viscosity (WBV), and fibrinogen (FIB) can lead to abnormal blood viscosity, resulting in reduced blood rheology

However, if you already have a history of migraines, hormonal or metabolic changes from the medication could act as a trigger

Integration with imaging can make metabolic biomarkers clinically meaningful

Time course: GI effects with both medications typically peak during dose increases and improve over weeks to months