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1,2,6 Because nonantimicrobial sulfonamides lack an arylamine group, they do not produce similar metabolites, which is the reason they do not cross-react in patients who have had nonIgE-mediated reactions to antimicrobial sulfonamides

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[1] The inflammation seen in KP could be caused by repeated mechanical irritation of the hyperkeratotic plugs, including scratching, but also by a decrease in antimicrobial peptides with accreted bacteria colonization, due to loss of sebaceous gland-derived antimicrobial peptides

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