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Modulation in the expression profile of various GR isoforms have been known to occur under various stress conditions (reviewed in Yousuf et al., 2012
The most commonly reported adverse effects in the Phase 2 trial included: Nausea the most prevalent side effect, particularly during dose escalation Vomiting Diarrhoea Constipation Decreased appetite (which, whilst contributing to weight loss, can be uncomfortable) Eructation (belching) Injection-site reactions (such as redness, bruising, or discomfort at the injection site) These effects are typically mild to moderate in severity and tend to be most pronounced during the first few weeks of treatment or following each dose increase
Taking it with food, coffee, or other beverages significantly reduces how much of the active ingredient is fully absorbed
FAO/WHO Food Standards: Rome, Italy
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doi: 10.1210/endocr/bqae167 26 AstrupA
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