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Note: Phase 2 trials also tested a 1 mg starting dose, which showed modest results
doi: 10.1530/RAF-21-0123 22 LiJJLiuLYWengJYinTLYangJFengHL
In the APP/PS1 mouse model of AD, TUDCA was able to restrain microglial and astrocyte activation and proinflammatory polarization and reduce A generation, thus improving the rescue of cognitive deficits [229]
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Its full amino-acid sequence is (D-Arg)9-LTLRKEPASEIAQSILEAYSQNGWANRRSAGGKRPPPRRRQRRKKRG, corresponding in three-letter notation to Leu-Thr-Leu-Arg-Lys-Glu-Pro-Ala-Ser-Glu-Ile-Ala-Gln-Ser-Ile-Leu-Glu-Ala-Tyr-Ser-Gln-Asn-Gly-Trp-Ala-Asn-Arg-Arg-Ser-Ala-Gly-Gly-Lys-Arg-Pro-Pro-Pro-Arg-Arg-Arg-Gln-Arg-Arg-Lys-Lys-Arg-Gly
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