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Oxidative Stress Reactive drug metabolites, alcohol, metals and environmental toxicants may increase demand for glutathione and other antioxidant systems
PMID 23000625
Metabolic pathways promoting cancer cell survival and growth
PMID 1591472.
Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible
Animals Adult albino rats weighing roughly 185 5 g were obtained from the animal house at the National Institute of Cancer and maintained in an observational environment unders daily observation
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