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these cells continue to proliferate at metformin concentrations that would normally suppress tumor cell growth ( In summary, metformin has demonstrated inhibitory effects on glioma through various mechanisms, including regulating cellular oxygen consumption, affecting mitochondrial respiration, inducing AMPK activation, and regulating oxidative stress, etc

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PubMed PMID: 10931172 Neurodegenerative disorders in humans: the role of glutathione in oxidative stress-mediated neuronal death