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Adjusting Semaglutide Doses and Considering Alternative Treatments If a plateau continues even with steady habits, it can be helpful to check whether the current dose still suits the persons needs

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In patients with DM2 the incretin response is diminished, but the insulinotropic effect of GLP-1 is conserved.28 Under normal conditions GLP-1 has a short half-life (approximately 2 min), as it is rapidly degraded by dipeptidylpeptidase 4, so GLP-1 analogues resistant to this enzyme have been developed for the treatment of DM2.29 arGLP-1: glucagon-like peptide 1 receptor agonist

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However, the total weight lost on GLP-1 medications far exceeds phentermine by the end of treatment

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Phase 1: the 0.25mg starting dose (5 units) Do not expect weight loss during this phase

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