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doi: 10.1164/rccm.202303-0558WS 4 BerstenADEdibamCHuntTMoranJ

In renal impairment, this axis contributes to a feedback loop driven by gut dysbiosis, systemic inflammation, oxidative stress, blood pressure dysregulations, and neurocognitive decline (Bugnicourt et al., 2013

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Clinical trials have not reported serious side effects at doses up to 1,000 mg per day