There is no universally correct day
Most patients report the experience as manageable with proper technique and preparation
However, the absence of burping does not mean the medication is not working, as individual experiences with side effects vary considerably
Full data is expected in mid-2026: which would put an FDA decision on the drug into late 2027 or 2028

People taking GLP-1 medications may experience a range of positive effects: Lower blood sugar levels, leading to improved diabetes control Promote weight loss, which can improve overall health and lower the risk of related medical problems Lower the risk of heart attacks, strokes, and kidney disease in people with diabetes or those at high cardiovascular risk Improve liver health in people with metabolic dysfunction-associated steatotic liver disease (MASLD) Help lower blood pressure and cholesterol, supporting overall heart health Reduce appetite and food cravings, making healthy eating patterns easier to maintain Less likely than some other diabetes medicines to cause low blood sugar or unwanted weight gain Can provide meaningful and lasting results for people who have struggled to lose weight with lifestyle changes alone Are there specific lifestyle changes that work best with these medications
Mol Cell Endocrinol , 198(1-2):8995