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The next costly and more effective comparator, oral semaglutide 14 mg, resulted in an ICER of $29,919 per QALY gained versus canagliflozin 300 mg

These medicines are primarily prescribed for the management of type 2 diabetes mellitus and, more recently, for weight management in adults with obesity or overweight with weight-related comorbidities

Diabetes 61:12501262 Nachnani JS, Bulchandani DG, Nookala A et al (2010) Biochemical and histological effects of exendin-4 (exenatide) on the rat pancreas

Its also approved for obstructive sleep apnea in populations who have obesity or are overweight with at least one weight-related condition

Furthermore, because of its extensive plasma protein binding, semaglutide is not expected to be removed through dialysis or other filtration methods, even in medical settings, with pharmacokinetics remaining largely unchanged even in end-stage renal disease

Collectively, these effects create a microenvironment conducive to cellular recovery and tissue repair in experimental models