comparing cardiovascular and kidney outcomes with tirzepatide vs. glp-1 agonists Renal effects of receptor in individuals type 2 diabetes: seeds of a promising future | Endocrine GLP-1 receptor agonists, including semaglutide

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Studies were selected based on the PICOS framework: Population: Adults (18 years) with overweight or obesity (BMI 25 kg/m2)

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[4] [5] Semaglutide works by mimicking the incretin hormone GLP-1, which stimulates insulin secretion in a glucose-dependent manner, suppresses glucagon release, slows gastric emptying, and reduces appetite through central nervous system pathways

rescue use) and employment of combination strategies with multi-agonist incretin therapies and/or anabolic/anti-catabolic agents

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