Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian society of endocrinology (SIE)
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Physiologically, GDF15 is expressed in many tissues at a low concentration, but increases in expression with tissue damage, cancer, metabolic diseases, CVD and inflammation
Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes
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