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Although the GAA altered MET availability in the dams (Motta et al., 2025), supplementation of GAA to heifers 63 days before breeding until d 63 of gestation, did not alter the methyl supply in fetal liver ( Maternal nutrition modulates fetal development and influences the offsprings performance postnatally (Santos et al., 2022

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Therefore, establishing a hypoxia-induced endothelial cell senescence model is crucial for studying these diseases

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Cancer Cell 24 , 450465 (2013)