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Frontiers in Nutrition, 11, 1398059

(Left) In liver cells, GLP-1 can mediate cholesterol efflux by acting directly on LXR, or by inducing an increase in ATP-binding cassette transporter A1 (ABCA1) mRNA through Ca2+/calmodulin (CaM)-dependent protein kinase kinase/CAM-dependent protein kinase IV/Prolactin regulatory element binding (CaMKK/CaMKIV/PREB), increasing apolipoprotein AI (apo AI) mRNA and promoter expression, and increasing apo AI secretion, thereby mediating intracellular cholesterol efflux

Recommended treatment protocol: 1000-2000 mcg of B12 given through injections or under the skin, at first daily or weekly

Ding W-G, Renstrm E, Rorsman P, et al

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