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Let the water trickle down the side
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As per the UK SmPC, the dose is escalated every 4 weeks to reach the target dose of 2.4 mg, with the option to delay a step by 4 weeks if not tolerated
This allows them to monitor digestive response before increasing the dosage, reducing the risk of side effects
It begs for confirmation and a bigger trial, and it raises the question of whether this is a pleotropic effect of the drug, versus only a weight loss effect. TAVR-MET trial Thirugnanam and colleagues randomized 260 patients (mean age 73 years
This can help improve the speed and completeness of dissolution
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