Insulin glargine (U-100)/lixisenatide: Insulin glargine/lixisenatide is indicated as an adjunct to diet and exercise to improve glycemic control in adults with T2D
Protein is crucial for GLP-1 users to maintain muscle mass during weight loss, with Christen typically recommending 20-30 grams per meal, or 1.2 grams per kilogram of body weight daily
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Research suggests that combined GIP and GLP-1 activation produces synergistic rather than merely additive effects on appetite and reward processing
Early keto adaptation may limit endurance and energy, particularly for individuals who engage in regular exercise
If side effects occur, the dose can be held steady until symptoms improve, ensuring progress continues without disruption