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For formulation composition design, it would be useful to conceive of a way to include the effect viscosity-reducing excipients may have on PPIs in the calculation of cluster size distribution and viscosity using these methods

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However, to date, there is only one randomized clinical trial of GLP-1 RAs (the ELIXA study) evaluating major cardiovascular events as their primary outcomes, and in this study, a neutral cardiovascular effect of lixisenatide was observed in high-risk diabetic subjects