Weight Liraglutide and semaglutide lowered weight by 2.3 and 3.6 kg more than placebo, respectively, in their CV outcome trials (6,7)
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PHASE 2 OBESITY TRIAL Triple-Hormone Receptor Agonist Retatrutide for Obesity A Phase 2 Trial Published in the New England Journal of Medicine in 2023, this study reported substantial reductions in body weight across multiple dose groups and helped establish Retatrutide as one of the most closely followed compounds in obesity research
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Muscle loss during caloric restriction is likely due to mechanisms that evolved to protect against food scarcity, since muscle is a major energy sink 17 , decreasing muscle mass helps minimize energy expenditure during caloric restriction