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Differential partial correlation networks associated with HRSD 17 scores at week 8 HRSD 17 scores at week 8 indicated the depression status of the patients post drug treatment

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The volumes of interest (VOIs) were localized at the ACC (30 20 20 mm 3 ), the thalamus (30 20 15 mm 3 ), and the rTPJ (30 20 30 mm 3 )

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The compound modulates neuronal activity in the lateral hypothalamus, specifically silencing GABAergic neurons that promote feeding behavior, thereby reducing the drive to consume food while enhancing satiety responses