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These properties pose a severe threat to human health

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For example, cortisol can decrease the expression of serotonin receptors, change transmission of norepinephrine, and minimize dopamine signaling

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Indeed, it has been suggested that certain cytokines that are upregulated during HIV infection have the capacity to induce the production of -MSH by oral melanocytes and keratinocytes and to mediate the upregulation of expression of MC1R by melanocytes, resulting in increased melanin production