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Current evidence suggests GLP-1 medications work best as long-term treatment, similar to blood pressure or cholesterol medications

"Procurement Strategies for Novel Therapeutic APIs: Risk Management and Supplier Evaluation." Pharmaceutical Procurement Management, 2024.

Cardiovascular benefits associated with some GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) observed in clinical trials are likely to diminish after discontinuation, though the exact persistence of these benefits remains uncertain

Detailed information on each outcome is provided in Supplementary Table S2